منابع مشابه
Partial purification of plasma thromboplastin antecedent (factor XI) and its activation by trypsin.
A persistent puzzle in our understanding of hemostasis has been the absence of hemorrhagic symptoms in the majority of patients with Hageman trait, the hereditary deficiency of Hageman factor (factor XII). One proposed hypothesis is that alternative mechanisms exist in blood through which plasma thromboplastin antecedent (PTA, factor XI) can become active in the absence of Hageman factor. In or...
متن کاملActivation of factor XI by products of prothrombin activation.
The prothrombinase complex converts prothrombin to α-thrombin through the intermediate meizothrombin (Mz-IIa). Both α-thrombin and Mz-IIa catalyze factor (F) XI activation to FXIa, which sustains α-thrombin production through activation of FIX. The interaction with FXI is thought to involve thrombin anion binding exosite (ABE) I. α-Thrombin can undergo additional proteolysis to β-thrombin and γ...
متن کاملA cofactor for factor XI activation.
mice carry mutations of the c-Kit gene, which obviously do not affect basophil biology. On the other hand, basophil-deficient Mcpt8DTR or basoph8 mice carry a transgenic receptor that mediates toxin-mediated cell death and mast cells in these mice remain intact. In mice deficient in IL-3, both mast cell and basophil generation are severely impaired only after parasite infection.6 Therefore, Cpa...
متن کاملActivation of Human Blood Coagulation Factor XI Independent of Factor XI1
Human blood coagulation factor XI was activated by either autoactivation or thrombin. These reactions occurred only in the presence of negatively charged materials, such as dextran sulfate (-Mr 500,000), sulfatide, and heparin. During the activation, factor XI was cleaved at a single Arg-Ile bond by thrombin or factor XIa to produce an amino-terminal 50-kDa heavy chain and a carboxyl-terminal 3...
متن کاملActivation of clotting factor XI without detectable contact activation in experimental human endotoxemia.
Evidence of factor XI (FXI) activation in vivo is scarce. In addition, it remains uncertain whether thrombin, factor XIIa (FXIIa), or perhaps another protease is responsible for FXI conversion. We investigated the activation of FXI in eight healthy volunteers after infusion of a low dose of endotoxin (4 ng/kg of body weight). Activation of prekallikrein FXII, FXI, and prothrombin was measured w...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)85787-3